Staff RNs Respond to Amiodarone-Related Phlebitis

By Ava Sammarco

Background and Significance:

Amiodarone is an important drug in combating dangerous and potentially fatal arrhythmias, but, when infused peripherally, it is particularly prone to damaging veins by vesicant extravasation.1 The spectrum of harm, from mild to severe, includes infiltration or extravasation, phlebitis, thrombophlebitis, necrosis, sepsis, and, potentially, death.Outcomes include pain, needed hyaluronidase treatment or plastic surgery, increased length of hospital and intensive care unit stays, and increased cost.1 Nurses are in a position to minimize these concerns by maximizing best practices in their care.

The low pH of amiodarone, from 3.5 to 4.5 creates a caustic environment.3 When in contact with di-(2-ethylhexyl)phthalate (DEHP) plasticizing agents in IV tubing, amiodarone precipitates into needle-like crystals, causing localized vein irritation and trauma2. The likelihood of precipitation affecting the tissue depends on administered “volume fraction”, calculated as a ratio of infused drug volume to blood flow volume. The lower this ratio, the lower the chance of precipitation.4

A literature search indicates that peripheral IV amiodarone results in an incidence of vein damage from 8% to 85%,2,3,4,5,6,7,8,9,10,11 with a weighted average of 18.3%. Recognizing this unacceptably high level, staff nurses on a vascular care floor at a midwestern teaching hospital determined to generate evidence-based change, reducing amiodarone associated phlebitis by 50%. 

Specific Aim:

A PICO question was formed: For adult patients treated with peripherally infused amiodarone, can phlebitis be reduced significantly solely by adhering to maximal protective elements within the scope of nursing practice? A literature search identified nurse-controlled standards, from IV site care to the infusion. The study was aimed at phlebitis resulting from 24-hour infusions, usually for atrial fibrillation, atrial flutter, and supraventricular tachycardia12,13, rather than for emergency use.

Study Cohort:

The baseline cohort included a convenience sample of 73 patients discharged from February 2017 through March 2018. Data were collected before announcing the study to avoid influencing a change in nursing practice. The incidence of phlebitis in this group was 46.6%. To utilize an alpha of 0.05 with a power of 0.80, with a binomial endpoint and a goal of decreasing phlebitis by 50%, a target of 65 subjects in each cohort was set. The intervention cohort comprised 65 subjects, discharged from April 2018 to January 2019.

Methods:

This study describes a multi-dimensional approach to minimize amiodarone related phlebitis. All components of the intervention fall within the scope of nursing practice, requiring no outside regulation or approval. Following data collection on the baseline cohort, an education component was presented to all nurses on the vascular care unit, including the rationale behind each intervention. Practices gleaned from a literature search to decrease phlebitis constituted an intervention termed “Best Bundle Practices”, which was applied to the second cohort. The endpoint was the presence or absence of phlebitis in the peripheral vein in which amiodarone was infused. All areas affecting the potential for infiltration or irritation were addressed: the IV site, its security, the IV delivery system, and the volume fraction of the medication as it infused.  

With few exceptions, amiodarone infusions in both cohorts followed the manufacturer-recommended protocol. This includes a 150 mg amiodarone bolus in 100 ml D5W (10 mg/ml) over 10 minutes (600 ml/hour), followed by amiodarone 900 mg in 500 ml D5W (1.8 mg/ml), infusing at 1 mg/minute (33.3 ml/hour) for 6 hours, and then 0.5 mg/minute (16.7 ml/hour) for 18 hours.14 Infusion duration varied, depending on the severity and refractory nature of the dysrhythmia, pre-medication with other antiarrhythmic agents, or incidence of hypotension. 

The Infusion Nurses Society recommends that amiodarone be infused in a dedicated line with a 0.22-micron filter next to the peripheral cannula.15 These precautions were followed in the baseline cohort. Nurses also assessed IVs with nurse-to-nurse handoffs and every 4 hours with an infusing IV. Non-DEHP tubing was not available.

Interventions: 

The Best Practices Bundle protocol included the above practices, and introduced the following interventions, along with supporting evidence:

1) To decrease contact with an irritating or caustic substance or formation of a precipitate within the vein, the use of non-DEHP tubing was added to the protocol.14 

2) Slim et al. demonstrated the occurrence of increased cellular damage at concentrations of amiodarone of 2 mg/ml or higher.4 Recognizing this, amiodarone manufacturers recommend infusion by central venous catheter for higher concentrations, thereby decreasing the volume fraction of amiodarone.14 Though suboptimal, amiodarone frequently is administered peripherally. 

Spiering produced a set of guidelines for amiodarone infusion. She demonstrates a change in phlebitis from 85% to 38%, a 55.2% reduction in incidence, utilizing a small sample, with n =34 in both the before and after samples. Spiering also attempted to utilize a more dilute infusion of amiodarone but was unable to obtain this from pharmacy.6 Once considered incompatible with isotonic saline, (NS) subsequent research has shown amiodarone and NS to be compatible.16 Nurses’ responses to a nursing blog indicated a diminishing incidence of phlebitis when infusing NS in a Y-port with amiodarone.17 

  To decrease the volume fraction, a second intervention involved dilution of amiodarone by nearly 50% by utilizing a co-infusion of NS in a Y-port nearest the infusion site. Because the subjects were cardiac patients, hypervolemia was a concern. In addition, the Infusion Nurses Society reports that IV infusions at a rate exceeding 50 to 90 ml/hr result in increased rates of phlebitis.15 Therefore, NS was infused at 25 ml/hr with the bolus and for the first 6 hours of the 24-hour infusion, and reduced to 15 ml/hr for the remaining 18 hours, totaling 420 ml in 24 hours. The new amiodarone concentration, near 1 mg/ml instead of 1.8 mg/ml, effectively lowered the volume fraction, and the higher pH of NS ameliorated the lower pH of amiodarone.4,17,18

3) To minimize phlebitis, the optimally sized catheter was placed in the optimal site. The Infusion Nurses Society recommends using the smallest possible cannula in a relatively large vein.15 An 18 or 20-gauge cannula was encouraged for maximal stability and minimal vein contact. Although a new IV was considered ideal, an analysis of IV age showed no positive correlation with the incidence of phlebitis. Assessment of selected IV for excellent condition and placement was preferred over the automatic placement of a new IV.

4) Nurses were asked to prioritize the use of an IV placed in a non-jointed area, as recommended by the Infusion Nurses Society, to alleviate the danger of cannula displacement or damage by flexion.15.

5) The Infusion Nurses Society recommends increased observation of IV sites dependent on the danger posed by extravasation.15 To decrease the severity of phlebitis should it occur, observation of the IV site was increased from every 4 hours to every 2 hours. 

Statistical Analysis: 

Data was entered into an Excel (Microsoft Corporation) spreadsheet and imported into SAS v9.4 (SAS Institute Inc.) for analysis. Discrete dichotomous endpoints were used, i.e., presence or absence of any injury to the vein. P-values were calculated using a chi-square test.

Results:

In the baseline cohort, 46.6% (n =34) of subjects demonstrated amiodarone related phlebitis.  In contrast, the intervention group showed an incidence of 24.6% (n = 16). This represents a decrease of 47.2% with the intervention applied. The P-value = 0.006. 

Conclusion:

The intervention showed both clinically and statistically significant results, indicating that attention to best nursing practices alone can have a marked impact on the reduction of peripherally infused amiodarone related phlebitis. While no single practice can be singled out as most effective, it appears that a more dilute solution plus the use of non-DEHP tubing offer promise as new standards of care. 

The results are consistent with the findings of Spiering6 in a similar study, though this is a larger study and includes a co-infusion of isotonic saline. Should repeated research confirm these results, it also might be possible to convince manufacturers to provide an alternate concentration of amiodarone. 

Limitations:

This represents a small study in a fairly homogenous, primarily Caucasian population. Further testing needs to be done to ascertain the reproducibility of results in a variety of populations. Additionally, utilization of separate portions of the Best Bundle protocol may serve to tease out which elements offer the greatest benefit and to determine whether all elements are necessary. 

References

  1. Fox AN, Villaneuva R, Miller JL. Management of amiodarone extravasation with intradermal hyaluronidase. Am J Health Syst Pharm. 2017; 74(19):1545-1548.
  2. Norton L, Ottoboni LK, Varaday A, et al. Phlebitis in amiodarone administration: incidence, contributing factors, and clinical implications. Am J Crit Care. 2013; 22(6):498-505.
  3.  Russell SJ, Saltissi S. Amiodarone induced skin necrosis. Heart. 2006; 92 (10): 1395.
  4. Slim AM, Roth JE, Duffy B, Boyd SY, Rubal BJ. The incidence of phlebitis with intravenous amiodarone at guideline dose recommendations, Mil Med. 2007; 172(12): 1279-1283.
  5. Halonen J, Loponen P, Järvinen O, et al.  Metoprolol versus amiodarone in the prevention of atrial fibrillation after cardiac surgery: a randomized trial. Ann Intern Med. 2010; 153 (11): 703-709. 
  6. Spiering, M. Peripheral amiodarone-related phlebitis: an institutional nursing guideline to reduce patient harm. J Infus Nurs. 2014; 37 (6): 453-460.
  7. de Fatima Suardi Martinho R, Rodrigues AB. Occurrence of phlebitis in patients on IV amiodarone, Einstein. 2008; 6(4): 459-462.
  8. Boyce BA, Yee BH. Incidence and severity of phlebitis in patients receiving peripherally infused amiodarone, Crit Care Nurse. 2012; 32(4): 27-34,71.
  9. Showkathali R, Earley MJ, Sporton S. Amiodarone induced thrombophlebitis, Emerg Med J. 2006; 23 (8): 660.
  10. Santangeli P, DiBiase L, Burkhardt JD, et al. Examining the safety of amiodarone, Expert Opin Drug Saf, 2012; 11(2): 191-214.
  11. 16. Mowry JL, Hartman LS. Intravascular thrombophlebitis related to the peripheral infusion of amiodarone and vancomycin. West J Nurs Res. 2011; 33 (3): 457-471.
  12. Siddoway, LA. Amiodarone: Guidelines for use and monitoring. Am Fam Physician. 2003; 68 (11): 2189-2197.
  13. Clemo, HF, Wood MA, Gilligan DM, Ellenbogen KA. Intravenous amiodarone for acute heart rate control in the critically ill patient with atrial tachyarrhythmias. Am J of Cardiol. 1998; 81(5): 594-598.
  14. Wyeth Pharmaceuticals Inc. Rx List: Cordarone IV.  https://www.rxlist.com/cordarone-iv-drug.htm  Reviewed 10-26-2018. Accessed November 23, 2019.
  15. Gorski L, Hadaway L, et al. Infusion nursing standards of practice. J Infus Nurs. 2016; 39 (1S); S51.
  16. Campbell S, Nolan PE Jr., Bliss M, Wood R, Mayersohn M. Stability of amiodarone hydrochloride in admixtures with other injectable drugs. Am J Hosp Pharm. 1986; 43 (4): 917-921.
  17. Baylor, D. (2013) Preventing phlebitis with amiodarone. AllNurses.com, Inc. website. http://allnurses.com/ccu-nursing-coronary/preventing-phlebitis-with-889688.html Accessed October 19, 2016.

Reddi, BA.  Why is saline so acidic (and does it really matter?). Int J Med Sci. 2013; 10(6):747–750.


Bio‐ Marie Langer, MA, RN, CCRN

Marie Langer, MA, RN, CCRN, has recently retired after 46 years of nursing. She spent the last 19 years of her career as a cardiology ICU nurse in St. Paul, MN. She has taught cardiology ICU classes and CCRN review classes through Twin Cities Health Professionals Education Consortium and has served as Decentralized Nurse Educator for her cardiology unit and the float pool. She is the communicating author and project coordinator for this quality improvement project aimed at applying evidence-based practice. She spends her retirement tutoring high school math and english students. She can be reached at atruczi@icloud.com.

85 comments on Staff RNs Respond to Amiodarone-Related Phlebitis

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    shall convince you: spyhackelite @gmail com. He has been of great help to me and i believe he will be to you.

  40. The truly scary thing about undiscovered lies is that they have a greater capacity to diminish us than exposed ones. When people cheat in any arena, they diminish themselves-they threaten their own self-esteem and their relationships with others by undermining the trust they have in their ability to succeed and in their ability to be true. Cheating is the most disrespectful thing one human being can do to another. If you aren’t happy in a relationship, end it before starting another one. respect a person who is loyal in a relationship, by cheating on him or her. If you succeed in cheating on someone, don’t think that the person is a fool, realize that the person trusted you much more than you deserve. If you notice any suspicious act on your partner if he or she is cheating. You need to write MR FRED to help you remotely spoof on the target phone to retrieve text messages, call logs, social media activities, bank information and many more. They deliver the best services and get you the peace of mind you deserve. Email:hackrontech @gmail com. Best wishes.

  41. Helena Bayes says:

    The best way to avoid a psychological breakdown after experiencing or having to deal with infidelity is to make sure you are not just assuming your partner is cheating, as a policy , don’t say they are cheating until you have gathered proof of their act, confrontation without evidence is just unacceptable, I contacted this Genius hacker Remotespywise at GMAL C O M when I was in the eye of the storm with my Ex husband i saw all his mails, Skype, Instagram, messages, kik, Facebook and even pictures he exchanged with his lover, but it was easier at the end really, having proof helps a lot. you never going to regret working with him, talk to him via Email: remotespywise a t gmail c o m

  42. Armenia says:

    My husband feels his way to smart by deleting all his WhatsApp MESSAGES, text messages, iMessages and many more but with the help of remotespyhacker @gmail com I proofed my husband wrong because With this hacker I got all deleted messages my husband has been deleting since 6 months back till date I got the chance to read all that he has been hiding from me, all thanks to you

  43. Yissendy Trinidad says:

    I always stood against people trying to hack their partner’s phone, until my cheating husband gave me every reason to spy on him. I’ve been suspecting his attitude lately and I really loved my man, so I was eager to find out the reason behind his sudden change of attitude. I contacted Fred Hacker who was recommended by a friend and after a few hours of contacting him, he gave me remote access to my husband’s phone and I saw all his day to day activities and I was able to confirm he was cheating. You can reach him on gmail through; hack4techspy @gmail com.

  44. Rena says:

    Honestly i gave up on hiring a online hacker due to the bad experienced i always encounter with them but this time i was really in urgent need for a legit one cos i needed to be sure what my partners plan is as he is avoiding me and always hiding hen making calls couple with his late night movement. i was so scared so i got a helping hand from a friend Hyung who introduced me with this expert hacker, i was scared and lost trust in him at first but after giving him a try in couple of hours i got access to my partner phone and saw his call recordings, hidden text messages, social accounts , hidden photos and more. Thank you [ Remote spy hacker @ gm ail . c om ] for been legit.

  45. Good says:

    CRYPTO RECOVERY EXPERT: Have you lost hope of ever recovering your money from scam brokers, crypto,, etc? I have good news for you and yes it is 97% possible for you to recover your money through a Certified Recovery Expert Hacker Steve. I had lost over $128,000 to a fake broker, and I lost hope of ever making profit through binary trading. After the loss, I had a long research on how to recover the lost funds. I came across Hacker Steve, a Specialized Recovery Expert who helps Scammed Victims recover their Lost Funds. After submitting my case, he worked on my case and all my funds were recovered back.

  46. Good says:

    Are you a victim of Investment, BTC, Forex, NFT, Credit, etc Scam? Contact Hackersteve911@gmail.com for quick recovery, and thank me later

  47. Biyu says:

    Most hackers online are the same , always disappointing and taking advantage of you. My partner always keep making me feel less of myself. He comes home late, takes late night calls and send secrets message to someone else i don’t know about, i tried talking to him about it but he yelled at me and says i complain alot. I couldn’t just keep quite so i hired a hacker to help out only for me to loose my funds to them without any job done. i felt so pained not until my cousin Natalya introduced to this great expert hacker ( remote spy hacker @ g m ail ) who offers phone hack, website , snap chat hack and more. This expert got my job done after couple of hours and now my partner is still surprised how i got to know about all his deleted chats, call recordings and more. thank you expert hacker

  48. Karla Marques says:

    I came to find out that there was a lot of things going on in my marriage even with the way my husband act really loyal to me, he was really a cheat and comes back home clean and act like nothing happen, i was browsing through a blog online and got to read about WAYNE and decided to try him out and in less than 4 hours i got all i wanted, he helped me spy into his whats-app, Facebook, Instagram, twitter, Skype, call logs, IM, Emails, messages, retrieve all deleted messages also i will advice all married women to do a little check on there husband to know whats is really going on some act clean and are not clean at all, contact hack4techspy @gmail com.

  49. Tuany Cristine says:

    I was asked to give my thoughts on hack4techspy @gmail com because I was pleased with how my score improved and how much they taught me. Well to whom it may concern, all I can say is that they are good at their job and if you need any cyber related help you can visit their email. Mind you i also got them to spy on my cheating spouse too and they did a good job where i could access his phone remotely without him noticing, you can do the same too just follow the process given to you by hack4techspy @gmail com trust me when there is nothing to worry about dealing with these kind of people.

  50. JUDITH LAWMAN says:

    I was asked to give my thoughts on hackrontech @gmail com because I was pleased with how my score improved and how much they taught me. Well to whom it may concern, all I can say is that they are good at their job and if you need any cyber related help you can visit their email. Mind you i also got them to spy on my cheating spouse too and they did a good job where i could access his phone remotely without him noticing, you can do the same too just follow the process given to you by hackrontech trust me when there is nothing to worry about dealing with these kind of people.

  51. GLORIA PEDRO says:

    Please beware there are many fake bitcoin mining/clouding out there, I have been a victim once but now a certified blockchain consultant and I know better. The whole plan was so smooth I could not doubt it. Bitcoin is actually a great investment option but one thing I discovered over time is that it is not possible to mine bitcoin so don’t be deceived. I invested $25000 on a particular website called eurekaminingblock, I monitored the profit yielding but was told to open a new blockchain account to receive my payout. A public wallet was imported into the account and I was made to believe that was my profit. The bitcoin was labelled non spendable and it took me 2 years to be able to access it without the knowledge of the company. The non spendable bitcoin is the scam out there now and a lot of people are falling victim of it. I found CM (a recovery expert and trader) on Quora who helped me access a significant part of my investment together with the profit without the knowledge of the company. You can reach him through his email :hackrontech @gmail com

  52. CHERRY says:

    I am not the first to recommend him because his recommendations can be seen everywhere but I am doing this because I am very happy, I am very happy because I made the right choice and that right choice is me chosen to follow my instincts and go with the good reviews i saw about hackrontech hacker, believe, if it’s not for that choice i made i would have still been in a very toxic relationship with my ex partner who was a serial cheat but all that is gone now thanks to Mr. RUSSSELL everyone deserves happiness that includes you so to get that happiness you deserve I reckon. contact the best in the game for spying and gaining access into phone remotely without having the device on your hands contact email ;hackrontech @gmail com.

  53. Maria Rodriguez says:

    All I ever wanted was a sweet and healthy relationship with my girlfriend but no matter how much I tried I knew something was wrong somewhere, so I employed a private investigator Hackerone975 @ g ma il C OM to help me spy on her phone. It was really heart breaking to realize that someone you’ve invested so much on has just been messing with my emotions. It’s really sad. But I’m happy I met Hackerone975 @ g ma il C OM Now I know I deserve better.

  54. Naomi Soroya says:

    ℙ𝕖𝕣𝕞𝕚𝕥 𝕞𝕖 𝕥𝕠 𝕥𝕖𝕝𝕝 𝕪𝕠𝕦 𝕒𝕓𝕠𝕦𝕥 𝕋𝕙𝕚𝕤 𝕘𝕣𝕠𝕦𝕡 𝕠𝕗 𝕔𝕪𝕓𝕖𝕣 𝕤𝕖𝕔𝕦𝕣𝕚𝕥𝕪 𝕠𝕡𝕖𝕣𝕒𝕥𝕠𝕣 𝕨𝕙𝕠 𝕔𝕒𝕟 𝕙𝕖𝕝𝕡 𝕨𝕚𝕥𝕙 𝕒𝕟𝕪𝕥𝕙𝕚𝕟𝕘 𝕪𝕠𝕦 𝕟𝕖𝕖𝕕, 𝕒𝕟𝕕 𝕒𝕝𝕤𝕠 𝕧𝕖𝕣𝕪 𝕗𝕒𝕤𝕥 𝕒𝕤 𝕨𝕖𝕝𝕝. 𝕆𝕟𝕖 𝕠𝕗 𝕥𝕙𝕖 𝕓𝕖𝕤𝕥 𝕙𝕖𝕣𝕖 𝕚𝕟 𝕥𝕙𝕖 𝕨𝕠𝕣𝕝𝕕 𝕤𝕠𝕞𝕖 𝕠𝕗 𝕥𝕙𝕖 𝕥𝕙𝕚𝕟𝕘𝕤 they do 𝕚𝕟𝕔𝕝𝕦𝕕𝕖𝕕 𝕊𝕡𝕪𝕚𝕟𝕘, 𝔻𝕖𝕧𝕚𝕔𝕖 𝕥𝕣𝕒𝕔𝕜𝕚𝕟𝕘, 𝕌𝕡𝕘𝕣𝕒𝕕𝕚𝕟𝕘 𝕠𝕗 𝕣𝕖𝕤𝕦𝕝𝕥𝕤, ℍ𝕒𝕔𝕜𝕚𝕟𝕘 𝕚𝕟𝕥𝕠 𝕒𝕟𝕪 𝕤𝕠𝕔𝕚𝕒𝕝 𝕞𝕖𝕕𝕚𝕒, 𝕗𝕚𝕩𝕚𝕟𝕘 𝕠𝕗 𝕔𝕣𝕖𝕕𝕚𝕥 𝕤𝕔𝕠𝕣𝕖 𝕒𝕟𝕕 𝕝𝕠𝕥𝕤 𝕞𝕠𝕣𝕖. 𝕨𝕚𝕥𝕙 𝕒 𝕘𝕣𝕖𝕒𝕥 𝕞𝕖𝕥𝕙𝕠𝕕 𝕠𝕗 𝕤𝕜𝕚𝕝𝕝𝕤 𝕒𝕟𝕕 𝕖𝕩𝕡𝕖𝕣𝕚𝕖𝕟𝕔𝕖. ℂ𝕠𝕟𝕥𝕒𝕔𝕥 HACKERONE975 : 𝔾 𝕞𝕒 𝕚𝕝: HACKERONE975 @ G MA IL C OM ‬. 𝕋𝕙𝕖𝕚𝕣 𝕥𝕖𝕒𝕞 𝕨𝕒𝕤 𝕒𝕓𝕝𝕖 𝕥𝕠 𝕙𝕖𝕝𝕡 𝕞𝕖. 𝔸𝕟𝕕 𝕀 𝕡𝕣𝕠𝕞𝕚𝕤𝕖𝕕 𝕥𝕙𝕖𝕞 𝕥𝕙𝕒𝕥 𝕀 𝕨𝕚𝕝𝕝 𝕣𝕖𝕗𝕖𝕣 𝕥𝕙𝕖𝕞 𝕥𝕠 𝕒𝕤 𝕞𝕒𝕟𝕪 𝕥𝕙𝕒𝕥 𝕟𝕖𝕖𝕕 𝕥𝕙𝕖𝕚𝕣 %𝟙𝟘𝟘 𝕤𝕖𝕣𝕧𝕚𝕔𝕖𝕤 𝕨𝕚𝕥𝕙 𝕘𝕦𝕒𝕣𝕒𝕟𝕥𝕖𝕖𝕕 𝕐𝕠𝕦 𝕔𝕒𝕟 𝕒𝕝𝕤𝕠 𝕔𝕠𝕟𝕥𝕒𝕔𝕥 𝕥𝕙𝕖𝕞.

  55. RECOVER YOUR LOST CRYPTOCURRENCY, USDT,BITCOIN LOST WALLET OPTIMISTIC HACKER GAIUS

    I was defrauded of a substantial amount of money on an online trading platform. I had absolutely lost hope until I discovered an OPTIMISTIC HACKER GAIUS on Reddit, which allowed me to recover all of my lost money in addition to any alleged gains. Permit me to share my story and how I managed to receive my money back.

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    email…. optimistichackergaius @ seznam.cz.

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